Dysembryoplastic Neuroepithelial Tumor (DNET) causing Refractory Focal Seizures

Dysembryoplastic neuroepithelial tumor (DNET) is relatively uncommon benign tumor, responsible for causing partial seizures in children, many of those cases may be medically refractory. The most common location is temporal lobe, as in this case (about 65% of cases). About 20% cases involve frontal lobe. The remainder of cases involve caudate nucleus, cerebellum and pons.Continue reading “Dysembryoplastic Neuroepithelial Tumor (DNET) causing Refractory Focal Seizures”

MRI Abnormalities in Canavan’s Disease- Leukodystrophy

9 month old child was brought with a history of developmental delay (both motor and speech delay) and seizures. The symptoms were progressively worsening. There was no family history of similar illness. On examination, the child had large head (macrocephaly) and spasticity of all 4 limbs. MRI brain showed megalencephalic appearance with symmetric increased signalContinue reading “MRI Abnormalities in Canavan’s Disease- Leukodystrophy”

New Guidelines for Migraine Prevention in Children and Adolescents

Migraine is common in children and adolescents and is a significant cause of disability. Migraine adversely affects their studies, games and other recreational activities. Over the years, newer evidences have been generated and the current guidelines have incorporated them. The key recommendations for prevention of headaches are: Topiramate is more effective than placebo in reducingContinue reading “New Guidelines for Migraine Prevention in Children and Adolescents”

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