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Polyminimyoclonus refers to involuntary, jerky, small amplitude, tremor-like movements, most commonly seen in hands. The commonest cause is degenerative anterior horn cell disease, commonly known as motor neuron disease or amyotrophic lateral sclerosis. These tremor-like movements (polyminimyoclonus) correspond to fasciculations in forearm muscles.


Amyotrophic lateral sclerosis (ALS) is a degenerative neurological disease affecting only the motor system. It is also referred to as motor neuron disease (MND) and is characterized by muscle wasting, weakness and fasciculations. Fasciculations refer to involuntary contractions/twitching of affected muscles. Affected muscles are wasted (thin) and weak. In this video, you can see fasciculationsContinue reading “FASCICULATIONS”

Wasting of First Dorsal Interossei (small muscles of hand)

In the picture above, you can see a depression in the first web space (between thumb and index finger). This is suggestive of wasting of first dorsal interosseous (FDI) muscles. This patient had bilateral C8-T1 lesion. Small muscle wasting can have varied localizations: Lower cervical cord lesion, anterior horn cell disease, C8-T1 root lesion, lowerContinue reading “Wasting of First Dorsal Interossei (small muscles of hand)”