Subependymal Calcification Demonstrated on SWI MRI in a Case of Tuberous Sclerosis


Susceptibility Weighted MRI images demonstrating subependymal calcification

Tuberous sclerosis is a multi-systemic genetic disease, which predominantly manifests with seizures and cutaneous manifestations (such as adenoma sebaceum). Abnormalities on brain scan include cortical tubers, subependymal nodules (sually calcified) and subependymal giant cell astrocytoma (SEGA). MRI is usually preferred over CT scan as tubers and SEGAs are better appreciated on MRI as compared to CT.

Calcifications can be also be appreciated on MRI, especially susceptibility weighted images (SWI), as seen in mRI images above.

This child had only manifested with seizures of two years duration, which were well controlled with sodium valproate. He was doing well in studies.

Published by Dr Sudhir Kumar MD (Medicine) DM (Neurology)

I am a doctor with 25 years experience. I have worked as a neurologist for about 20 years. Educating public and healthcare professionals is very dear to me. This is possible due to my interactions with thousands of patients and their caregivers. I salute the patients who suffer and it is our duty to minimise suffering by preventing diseases and ensuring prompt diagnosis and treatment of those already affected.

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