Anti-MDA-5 Antibody positive Dermatomyositis

Ulcerated Gottron’s Papules (Source: NEJM July 25, 2019)

Clinically amyopathic dermatomyositis (CADM) is a subset of dermatomyositis, where there is skin involvement without myositis. There is no or little muscle weakness and serum CPK levels are normal or mildly elevated. Patients with one of the variants of CADM present with ulcerated Gottron’s papules and rapidly progressive interstitial lung disease (RP-ILD). Anti-MDA5 (anti-melanoma differentiation-associated antibody is positive in about 60-70% of CADM patients.

The disease is rapidly progressive and is associated with high mortality. Aggressive immunotherapy with high-dose corticosteroids, cyclosporine and intermittent intravenous cyclophosphamide is recommended for anti-MDA5 antibody-positive CADM.

Published by Dr Sudhir Kumar MD (Medicine) DM (Neurology)

I am a doctor with 25 years experience. I have worked as a neurologist for about 20 years. Educating public and healthcare professionals is very dear to me. This is possible due to my interactions with thousands of patients and their caregivers. I salute the patients who suffer and it is our duty to minimise suffering by preventing diseases and ensuring prompt diagnosis and treatment of those already affected.

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